An In vitro Study on Curcumin Delivery by Nano-Micelles for Esophageal Squamous Cell Carcinoma (KYSE-۳۰)

Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcuminchr('۳۹')s bioavailability. Cyclin D۱ is overexpressed in ESCC and curcumin may change its expression. Methods: In this study, the effect of SinaCurcumin®, a novel nano-micelle product containing ۸۰ mg curcumin, on the growth of KYSE-۳۰ cells and expression of cyclin D۱, was investigated. Paclitaxel and Carboplatin served as reference drugs. Results: Nano-curcumin increased cell cytotoxicity, decreased IC۵۰, and down-regulated of cyclin D۱. However, treatment of cells with nano-curcumin might result in multidrug resistance. Conclusions: Nano-curcumin suppressed proliferation of KYSE-۳۰ cells and expression of cyclin D۱ although its use in combination with other chemotherapeutic agents requires further testing.

Keywords:

Curcumin , Cyclin D۱ gene , Drug resistance , KYSE-۳۰ cells , Nano-Micelle