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Title

Quantitation of Vascular Endothelial Growth Factor and Interleukin-۶ in Different Stages of Breast Cancer

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 6، شماره: 1
Year: 1396
COI: JR_RBMB-6-1_005
Language: EnglishView: 29
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Authors

Kabbathi Raghunathachar Sahana - Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, Jagadguru Sri Shivarathreeswara University, Mysore, India.
Prashant Akila - Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, Jagadguru Sri Shivarathreeswara University, Mysore, India.
Vishwanath Prashant - Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, Jagadguru Sri Shivarathreeswara University, Mysore, India.
Bellekere Sharath Chandra - Department of Surgery, JSS Medical College, Jagadguru Sri Shivarathreeswara University, Mysore, India.
Maduvanahalli Nataraj Suma - Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, Jagadguru Sri Shivarathreeswara University, Mysore, India.

Abstract:

Background: Determination of the impact of angiogenesis on tumor development and progression is essential. This study aimed to determine the serum levels of Vascular endothelial growth factor (VEGF) and Interleukin ۶ (IL-۶) in breast carcinoma, and to correlate them with tumor size, lymph node involvement, and cancer stage. Methods: Under aseptic precautions ۵ ml of venous blood was collected from ۳۷ breast cancer patients and ۲۰ healthy females after obtaining due consent and ethical committee clearance. Serum levels of VEGF and IL-۶ were determined by enzyme-linked immunosorbent assay (ELISA). Results: Serum IL-۶ and VEGF levels were both significantly greater in patients than controls (P = ۰.۰۰۱, P = ۰.۰۰۱, respectively). The serum IL-۶ and VEGF levels also significantly correlated with TNM staging (P = ۰.۰۰۱, P = ۰.۰۰۱). Serum IL-۶ and VEGF positively correlated with each other (r۲ = ۰.۶۶۸, P = ۰.۰۱). Serum IL-۶ and VEGF levels did not correlate with tumor size (P = ۰.۴۵, P = ۰.۱۷) or lymph node metastasis (P = ۰.۹۵, P = ۰.۶۸). Conclusions: Serum IL-۶ and VEGF were greater in breast cancer patients than controls. The levels increased with advanced tumor, nodes, metastasis (TNM) staging, thus correlating with the patients’ prognoses. Serum IL-۶ and VEGF levels can be used as diagnostic tools and prognostic factors in breast cancer.

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This Paper COI Code is JR_RBMB-6-1_005. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Raghunathachar Sahana, Kabbathi and Akila, Prashant and Prashant, Vishwanath and Sharath Chandra, Bellekere and Nataraj Suma, Maduvanahalli,1396,Quantitation of Vascular Endothelial Growth Factor and Interleukin-۶ in Different Stages of Breast Cancer,https://civilica.com/doc/1263036

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