Protective Effects of Withania somnifera Root on Inflammatory Markers and Insulin Resistance in Fructose-Fed Rats

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 10 شهریور 1400


Background: We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-۶ (IL-۶) in fructose-fed rats. Methods: Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=۱۲); Group I as control, Group II as sham-treated with WS by ۶۲.۵mg/g per diet, Group III fructose-fed rats received ۱۰%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-۶, and TNF-α levels in sera. Results: Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-۶, and TNF-α levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < ۰.۰۵) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-۶, and TNF-α. Conclusion: Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.


Zahra Samadi Noshahr

Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran

Mohammad Reza Shahraki

Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran

Hassan Ahmadvand

Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran

Davood Nourabadi

Department of Physiology, Iran University of Medical Sciences, Tehran, Iran

Alireza Nakhaei

Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran