Reza Ebrahimzadeh-Vesal - Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Roza Azam - Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Arvin Ghazarian - Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mogge Hajesmaeili - Department of Biology, Islamic Azad University of Parand, Tehran, Iran.
Najmeh Ranji - Department of Genetics, Faculty of Sciences, Islamic Azad University, Rasht Branch, Rasht, Iran.
Mohammad Reza Ezzati - Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehrdad Sadri - Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Ali Mohammadi - Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Siamak Khavandi - Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before ۲۰ weeks of gestation, which occurs in approximately ۵% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is considered as a significant risk factor for recurrent pregnancy loss. The inherited predisposition to thrombophilia is most often associated with factor V Leiden mutation, prothrombin G۲۰۲۱۰A mutation, and methylenetetrahydrofolate reductase C۶۷۷T and A۱۲۹۸C gene variants. The net effect is an increased cleavage of prothrombin to thrombin and excessive blood coagulation.

Hereditary thrombophilia, Factor V Leiden mutation, Recurrent pregnancy loss