Evaluation of Serum ۲۵-hydroxyvitamin D Levels in Children with The First Episode of Seizures

Background: Seizures have been prevalent among children leading to critical complications and death in some cases, investigation of the reasons for seizures is of great importance. The aim of this investigation was to assess the influence of ۲۵-hydroxyvitamin D deficiency on seizures. Materials and Methods: This study was a case control study and carried out on ۱ to ۱۶-year-old children of Besat Hospital of Sanandaj, Kurdistan province, Iran, with the first episode of seizures (case) and children who were caming for routine laboratory checkup (control) in the year ۲۰۲۰.Serum ۲۵-hydroxyvitamin D level was measured by chemiluminescence immunoassays methods of blood sample for both case &control groups. The required data were collected and entered in SPSS software version ۲۱.۰ to be analyzed. A p-value less than ۰.۰۵ was considered as the significance level. Results: Total individuals of ۱۲۰ children (۷۲ (۶۰%)boys) with an average age of ۴۶.۷۷+۴۰.۵ months were selected for the investigation.Sixty-two patients(۵۱.۷%)of the children received an appropriate vitamin D supplement, and prevalence of vitamin D supplementation use was higher in case group(P=۰.۰۱۱).The average serum level of ۲۵-hydroxyvitamin D in individuals was ۳۱.۳۶+۱۹.۰۱,and the average serum level of vitamin D in the patient group was greater than that of the control group(P=۰.۰۰۳).The frequency of ۲۵-hydroxyvitamin D deficiency was higher in the control group(p=۰.۰۰۱). Conclusion: Based on the obtained results, an important conclusion can be reached that seizures in children were not effectively prevent by normal vitamin D supplements.

Keywords:

Seizures , serum vitamin D , Children