Mehdi Jahanbakhshi - Caspian Faculty of Engineering, College of Engineering, University of Tehran,Rezvanshar, P.O. Box ۴۳۸۴۱-۱۱۹, Iran
Saeed yari - Caspian Faculty of Engineering, College of Engineering, University of Tehran,Rezvanshar, P.O. Box ۴۳۸۴۱-۱۱۹, Iran
ehsan Shahrousvand - Department of Chemistry, Isfahan University of Technology, Isfahan, ۸۴۱۵۶-۸۳۱۱۱, Iran
Mohsen Shahrousvand - Caspian Faculty of Engineering, College of Engineering, University of Tehran,Rezvanshar, P.O. Box ۴۳۸۴۱-۱۱۹, Iran

A successful synthesis of amphiphilic copolymer poly (vinyl alcohol- methyl methacrylate) with ۱,۴-Butanediol dimethacrylate as a cross-linking agent was prepared using emulsion polymerization. PVAc-PMMA copolymer was characterized by degree of conversion, rate of polymerization, FTIR, and FE-SEM techniques. The Optimal sample was hydrolyzed and PVA-PMMA nanoparticles were obtained by comparison of the FTIR for the original PVAc-PMMA and the produced PVA-PMMA. The crosslinked PVA-PMMA was further loaded with methotrexate, and the drug release was observed for a total of ۹۶ h at a pH of ۵.۸ and ۷.۴. The developed nanoparticles present great potential as a system for biomedical applications.

PVA-co-PMMA, Polymer nanoparticles, Methotrexate, Drug delivery