Application of MgO@PMO-IL in the three-component reactions for the diastereoselective synthesis of novel spiro- furans

The synthesis of novel Spiro-furan derivatives via a three-component reaction of active methylenes, N-phenacyl pyridinium salts and α-dicarbonyl compounds. This reaction in the present of MgO nanoparticles on ionic liquid based periodic mesoporous organosilica (MgO@PMO-IL) were achieved in high efficiency to excellent yields with a simplework-up procedure and short reaction time, and the catalyst can be also recovered on efficiency reused in seven subsequent reaction conditions. Spiro-furan derivatives have many medicinal properties, So they have received a lot of attention.

Keywords:

Spiro-furans , Multi component reaction , Periodic Mesoporous Organosilica