Glucocorticoids could be safe in COVID-۱۹; a case series

Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_RHRE-5-4_002

تاریخ نمایه سازی: 20 شهریور 1400

Abstract:

 Severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) is a novel virus which has led to a pandemic. There is no approved treatment for coronavirus disease ۲۰۱۹ (COVID-۱۹). Over time, physicians came to understand that in some severe patients, glucocorticoids could be considered as a second line treatment option. As there are a limited number of reports addressing the use of glucocorticoids (GCs) in patients with moderately severe COVID-۱۹, this article presents the results in patients who referred to our national team and received glucocorticoids as part of their medication. This descriptive and prospective study iincludes ۳۵ clinically-diagnosed moderate to severe COVID-۱۹ cases in outpatient and inpatient settings. Patients received intravenous dexamethasone, oral prednisolone, and pulsed methylprednisolone. Demographic data, clinical signs and symptoms, laboratory and chest CT findings of patients were recorded. On average Men comprised ۶۰% of this group of patients. On admission Lymphocyte counts were depleted in a majority of patients (۵۴.۳%). Shortness of breath, O۲ sat, and respiratory rate improved ۴۸ to ۷۲ hours after administration of glucocorticoids. Almost all patients had favorable clinical courses were improved during treatment with glucocorticoids, except one who had superimposed bacterial and candida infection. CT scan findings showed bilateral peripheral patchy infiltrations with ground glass opacities as the dominant pattern of lung involvement (۶۰%). One patient was admitted to the intensive care unit. The results of our study showed that the administration of glucocorticoids in the early stages of COVID-۱۹ disease is not only effective, but is also safe and prevents the progression of the disease. 

Authors

Sina Owlia

Department of Medicine, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

zohreh akhoundimeybodi

Infectiologist, Fellowship Of Prevention And Control Of Nosocomial Infections, Infectious diseases research center, shahid sadoughi hospital, shahid sadoughi university of medical sciences, Yazd, Iran

Golbarg Mehrpoor

Alborz University of Medical Sciences, Karaj, Iran.

Mehrdad Aghaei

Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Zahra Mirfeizi

Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohammad Bagher Owlia

Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Seyed Ruhollah Mousavinasab

Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.