Comparative Evaluation of Cytotoxicity of Fluoride Varnish as Root Canal Sealer against L۹۲۹ Mouse Fibroblasts with Conventional Endodontic Sealers
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
View: 239
This Paper With 9 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JDMT-10-3_002
تاریخ نمایه سازی: 24 شهریور 1400
Abstract:
Introduction: This study aimed to assess the cytotoxicity of Duraflur fluoride varnish as root canal sealer against L۹۲۹ mouse fibroblasts in comparison with four commonly used conventional endodontic sealers in the first ۴۸ hours of exposure. Methods: In this in vitro, experimental study, L۹۲۹ mouse fibroblasts were exposed to ۱/۱, ½, ¼ , and ۱/۸ concentrations of Duraflur fluoride varnish, AH Plus, Fill Canal, MTA Fillapex, and AH۲۶ sealers. After ۴۸ hours, the methyl thiazolyl tetrazolium (MTT) assay was performed to assess the cytotoxicity of sealers. Cell viability was determined as the percentage of viable cells compared with the control group. The results were analyzed using one-way ANOVA followed by the Tukey’s post hoc test for multiple comparisons.. Results: MTA Fillapex had the lowest and AH۲۶ had the highest cytotoxicity (p <۰.۰۵). Fluoride varnish showed high cell viability in ۱/۸ concentration (۹۱.۰۹%). Its cytotoxicity was close to that of AH Plus with no significant difference (P=۰.۴۹) but it had higher cytotoxicity than Fill Canal and Fill Apex (p <۰.۰۵). Fluoride varnish in ۱/۱ and ۱/۸ concentrations showed significantly higher cell viability than AH۲۶ (p <۰.۰۰۱). Conclusion: Fluoride varnish sealer has acceptable biocompatibility comparable to that of conventional sealers. It has lower cytotoxicity than AH۲۶.
Keywords:
Authors
Erfan Hosseini
Private Practice, Nushahr, Iran
Mahdi Lomee
Endodontist, Sari, Iran
jamshid Yazdani charati
Professor, Department of Biostatistics, Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
Abolfazl Hosseinnataj
Assistant Professor,Department of Biostatistics ,Faculty of health,Mazandaran University of Medical Sciences,Sari, Iran
salma omidi
Assistant Professor, Department of Endodontics, Dental research center, Mazandaran University of Medical Sciences, Sari, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :