Ladan Kashani - Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ashraf Moini - Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Tayebeh Esfidani - Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Nazila Yamini - Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
shima Mohiti - Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nearly ۲۵-۵۰% of infertile women have endometriosis. There are reports of disorders in the expression of granulocyte colony-stimulating factor (G-CSF) receptors in women with endometriosis. Objective: To examine the effect of intrauterine administration of G-CSF in in vitro fertilization (IVF) cycles on the fertility rate of infertile women with moderate-to-severe endometriosis. Materials and Methods: This clinical trial was conducted on ۶۶ infertile women with moderate-to-severe endometriosis, undergoing IVF and intracytoplasmic sperm injection (ICSI). The participants were allocated into two groups via simple randomization: the G-CSF (n = ۲۷) and control (n = ۳۹) groups. In the G-CSF intervention group, on the oocyte pick-up day, immediately after an ovarian puncture, ۳۰۰ μg of G-CSF was injected through a transcervical catheter under abdominal ultrasound guide to visualize flushing into the uterine cavity. Women in the control group received no intervention. The two groups were evaluated for clinical pregnancy. Results: No significant difference was noted in the demographic characteristics of the two groups. The rate of clinical pregnancy was ۲۸.۲% in the control group and ۲۵.۹% in the G-CSF group, indicating no significant difference (p = ۰.۸۳). Conclusion: The results showed that the intrauterine injection of G-CSF had no effects on pregnancy in women with stage-۳/۴ endometriosis undergoing IVF.

G-CSF, In vitro fertilization, Endometriosis, Pregnancy, عامل تحریک کلنی گرانولوسیت (GCSF), لقاح داخل رحمی آزمایشگاهی, آندومتریوز