Mechanical Properties of Clay-Based Polyurethane Nanocomposite in Medical Application

Publish Year: 1400
نوع سند: مقاله کنفرانسی
زبان: English
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ICNNA02_029

تاریخ نمایه سازی: 4 مهر 1400

Abstract:

Polyurethane (PU) is a synthetic polymer obtained by polycondensation process of isocyanates and polyols, and for some cross-linked products with a third component as an extender. It is one of the most versatile macromolecular compounds, and it contains soft and hard segments. Beside (PU)'s physicomechanical and chemical properties, which make them suitable to be used in many engineering areas, they are biocompatible, biodegradable, bioabsorbant, and bioinert, characteristics which recommend them to be used in different medical areas.In this paper biodegradable polyurethane was synthesized by preparing aqueous polyurethane dispersion having poly(caprolactone) and poly(ethylene glycol) as soft segments. Montmorillonite particles were delaminated within the waterborne polyurethane to produce a nanocomposite. The triamcinolone acetonide (TA), an important corticoid drug, was dispersed into the nanocomposite followed by a drying step to produce an implantable drug delivery system. Wide angle (WAXD) results suggested.The presence of montmorillonite particles in the nanocomposite reduced the rate of TA release as compared to the pure polyurethane and enhanced the mechanical properties of the polymer. The overall results indicate that montmorillonite clay-based polyurethane nanocomposite could be potentially applied as local TA delivery system.

Authors

Ahmadreza MasoudArdekani

Nurse anesthetist