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Title

Continuous and size-controlled preparation of ibuprofen nanosuspension using membrane crystallization method

Year: 1400
COI: ICNNA02_260
Language: EnglishView: 20
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Authors

Atoosa Haghighizadeh - Department of polymer chemistry, kish International Campus, University of Tehran, Tehran, Iran
Hossein Mahdavi - School of Chemistry, College of Science, University of Tehran, Tehran, Iran
Omid Rajabi - Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

This study demonstrates the continuous and low-cost synthesis of ibuprofen nanosuspension using a hand-made porous hollow fiber antisolvent crystallizer. The effect of pertinent factors, including the inlet velocity, temperature, and surfactant's concentration on the final size of nanosuspension, were systematically studied using experimental design. Statistical analysis suggested the optimal range of parameters (V=۴۵ mL/min, C=۰.۰۱۱ mM, and T=۳۰ °C) for obtaining ibuprofen nanosuspension in a size range of ۳۰۰-۴۰۰ nm desired for intramuscular injection purposes. According to the in vitro analysis, the complete release of optimized ibuprofen nanosuspension takes only ۴۰ minutes, which confirmed the enhanced dissolution rate of the synthesized drug. The obtained nanosuspension is physically stable over three months, which makes them attractive candidates for practical applications.

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This Paper COI Code is ICNNA02_260. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1274877/

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Haghighizadeh, Atoosa and Mahdavi, Hossein and Rajabi, Omid,1400,Continuous and size-controlled preparation of ibuprofen nanosuspension using membrane crystallization method,2nd International Conference on Nanotechnology & Nanoscience,Tehran,https://civilica.com/doc/1274877

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Type of center: دانشگاه دولتی
Paper count: 67,801
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