Habibeh Nasab - Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran
Moghaddameh Mirzaee - Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
Karim Ebrahimpour - Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
Majid Hashemi - Corresponding author: Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

Background: Exposure of children and adolescents to endocrine disrupting chemicals (EDCs) causes the development of non-communicable diseases. Triclosan (TCS) is a fat-soluble antimicrobial agent, and methyl-triclosan (MTCS) is the predominant metabolite of TCS. The increasing use of consumables TCS (toothpaste, mouthwash, personal care products) in human has raised concerns about human health. Methods: The urinary concentrations of TCS and MTCS were measured by GC/MS. Lipid profiles (TG, TC, LDL, and HDL), anthropometric parameters (WC, BMI z-score, and BMI), FBS, SBP, and DBP tests were performed on ۷۹ children and adolescents. Results: Of ۷۹ people included as the study population, ۴۲ subjects (۵۳.۱۶%) were males. Most of the study population as ۳۲ subjects (۴۰.۵۰%) were obese. The mean concentrations of TCS and MTCS in the obese population were ۵.۴۷ ± ۲.۹۹ and ۲.۳۲ ± ۱.۰۴ µg/L, respectively. After adjusting for possible confounding factors, the results showed that a one-unit increase in DBP caused a ۰.۰۳ units increase in TCS levels in male subjects (P = ۰.۰۱). A one-unit increase in DBP also caused a ۰.۰۲ units increase in MTCS (P = ۰.۰۰۱). There was a significant relationship between TCS and HDL (OR = ۰.۹۰, P = ۰.۰۰۵), LDL (OR = ۱.۱۳, P = ۰.۰۱), and TG (OR =۱.۰۵, P < ۰.۰۰۰۱). There was also a significant relationship between MTCS and HDL (OR = ۰.۸۸, P = ۰.۰۰۱), LDL (OR = ۱.۰۳, P = ۰.۰۰۹), and TG (OR = ۱.۰۴, P < ۰.۰۰۰۱). Conclusion: According to the results, there is a relationship between TCS, MTCS, and predictive indicators of cardiovascular diseases and obesity.

Triclosan, Methyl triclosan, Cardiovascular disease, Obesity, Endocrine disrupter, Children, Adolescent