Effects of Cinnamon Extract Consumption and Swimming Exercise on the Expression of ATGL and CGI-۵۸ in the Visceral Adipose Tissue of Streptozotocin-induced Diabetic Rats

Introduction: Diabetes is a widespread disease, and various techniques are used for its prevention, control, and treatment, including physical exercises and medicinal herbs. Natural medicines and exercise are comparatively inexpensive and cause fewer complications compared to chemical drugs. The present study aimed to evaluate the effects of a swimming course and cinnamon extract consumption on the expression of adipose triglyceride lipase and CGI-۵۸ in the visceral adipose tissue of streptozotocin-induced diabetic rats. Methods: This experimental study was conducted on ۲۸ diabetic rats, which were randomly divided into four groups of seven, including ۱) control (C),۲) cinnamon use (Ci),۳) swimming course(S), and ۴) cinnamon extract with swimming (S+Ci). The animals received the intended treatment for six weeks in packs of three and four and five classes per week, while the rats in groups two and four received ۲۰۰mg/kg of cinnamon orally every day for six weeks. Data analysis was performed using the one-way analysis of variance (ANOVA) and Tukey’s post-hoc test at the significance level of P≤۰.۰۵۰. Results: The results of ANOVA indicated that ATGL gene expression in the S (P=۰.۰۴) and S+Ci groups (P=۰.۰۰۰۱) was significantly higher than the control group. In addition, ATGL gene expression in the S group (P=۰.۰۰۰۶) was higher compared to the Ci group, while it was significantly higher in the S+Ci group (P=۰.۰۰۰۱) compared to the Ci and S groups. CGI-۵۸ gene expression in the S+Ci group (P=۰.۰۰۰۱) was also significantly higher than the control, S, and Ci groups, while it was significantly higher in the S group (P=۰.۰۳۶) compared to the Ci group. Conclusion: According to the results, swimming exercise and cinnamon extract consumption increased the expression of CGI-۵۸ and ATGL protein in the diabetic rats. Therefore, it seems that CGI-۵۸ plays a key role in the activation of lipolysis by ATGL, and higher CGI-۵۸ could increase ATGL, which ultimately accelerates the lipolysis process, reduces fat, and improves insulin resistance in the visceral adipose tissue.

Keywords:

Cinnamon extract , Swimming training , CGI-۵۸ , ATGL , Diabetic rats