Skin manifestations associated with COVID-۱۹: A meta-analysis from Case Reports/Case Series

Background and Aim : Since the onset of the ۲۰۱۹-nCoV disease (COVID-۱۹), many skin manifestations have been reported in COVID-۱۹ patients. This study aims to provide a systematic review and meta-analysis of various skin manifestations among patients with COVID-۱۹ through case reports/case series and prevalence studies. Methods : A systematic literature search strategy was conducted by reviewing original research articles published in Medline, Web of Science, and Embase databases in ۲۰۲۰. Statistical analysis was performed using STATA software, version ۱۴.۰ (Stata Corporation, College Station, Texas, USA) to report the global prevalence of skin manifestations among patients with COVID-۱۹. Results : Forty-three studies (۳۵ articles were case reports/case series, and ۸ articles were prevalence studies) were included in our study. A meta-analysis of prevalence studies showed that skin manifestations among patients with COVID-۱۹ were reported in four countries (China, Thailand, France, and Italy), with an overall prevalence of ۱.۰% [(۹۵% CI) ۰.۱–۱.۹] among ۲,۶۲۱ patients. Evaluation of the results of the case reports/case series revealed that, out of ۵۴ patients with COVID-۱۹, ۴۸ patients (۸۸.۸%) showed skin manifestations. Erythematous rash (۵۹.۱%) and urticaria (۱۴.۸%) were the most common skin manifestation reported in studied patients. Conclusion : Infection with ۲۰۱۹-nCoV may lead to skin manifestations with various clinical symptoms. These clinical features combined with clinical symptoms of COVID-۱۹ may aid in the timely diagnosis of patients with COVID-۱۹.

Keywords:

coronavirus , ۲۰۱۹-nCoV , COVID-۱۹ , skin manifestations , meta-analysis