Synthesis of new antibacterial dental monomer by ۵-hydroxy-۳-phenyl-۱H-pyrazole-۱-carbothioamide and Investigation of its compressive strength

Background and Aim : Secondary caries is the most important reason for replacement and removal of restorative materials contains composite resins because caries is an infectious complication and many bacteria, including Streptococcus mutans and lactobacilli, have been isolated from cariogenic plaques, and given that composites base resins increase the growth of Streptococcus Therefore, the use of composite resins that have antimicrobial properties in the prevention of secondary decay will be very useful in this study, we synthesized ۵-hydroxy-۳-phenyl-۱H-pyrazole-۱-carbothioamide as a new antibacterial compound and used it in dental composite and Investigated of its compressive strength.Methods : In this experimental study, ۵-hydroxy-۳-phenyl-۱H-pyrazole-۱-carbothioamide was synthesized by reaction between Thiosemicarbazid and Ethyl benzoylacetate and the antibacterial activity of flowable dental composites containing ۰–۵ wt% ۵-hydroxy-۳-phenyl-۱H-pyrazole-۱-carbothioamide and also of their compressive strength on flowable dental composites were investigated. Statistical analysis was performed using one way ANOVA test (P < ۰.۰۰۱). Results : The direct contact test demonstrates that by increasing the ۵-hydroxy-۳-phenyl-۱H-pyrazole-۱-carbothioamide content, the bacterial growth is significantly diminished (p<۰.۰۰۱). the mean of compressive strength results show no significant difference between ۰-۳% of groups (p>۰.۰۰۱). Conclusion : Incorporation of ۵-hydroxy-۳-phenyl-۱H-pyrazole-۱-carbothioamide into flowable dental resin composites in ۴% wt can reduce the activity of Streptococcus mutans

Keywords:

۵-hydroxy-۳-phenyl-۱H-pyrazole-۱-carbothioamide , Streptococcus mutans , flowable dental resin composites , secondary caries .