Diagnosis of Helicobacter pylori by serological and invasive pathology in Shahr e kord patients

Background and Aim : Helicobacter pylori is a gram-negative, helical-negative bacterium found in the gastric mucosa and is the leading cause of gastric ulcer and chronic gastritis and is usually asymptomatic. The bacterium is more prevalent in developing countries. The aim of this study was to evaluate and compare invasive and serological methods in the diagnosis of Helicobacter pylori Methods : This cross-sectional laboratory study was performed on ۲۳۳ patients in which biopsy specimens were randomly collected from hospitals in Shahr e kord in ۲۰۱۹. Gastric and duodenal antrum biopsy was performed by pathology and staining (H&E) and stabilization, and serological antibody (IgG) was measured by ELISA to detect Helicobacter pylori. The data were analyzed using SPSS statistical software.Results : prevalence of infection in the age group (۲۷-۳۵ years) ۳۸% shows the importance of biopsy sampling and tissue staining among young people. This study also showed that antibody titration alone is not sufficient and invasive pathology sampling is required for final diagnosis. In this study, no significant relationship was observed between polymorphisms in the control group and patients with HBV infection.Conclusion : According to the present study, the age range of ۲۷ to ۳۵ years was shown as the most infected group with this bacterium. This difference may be due to differences in diet and geographical sampling range. Finally, considering the importance and consequences of Helicobacter pylori infection, the obtained epidemiological information and data analysis, and considering the increasing prevalence in the young age group, it is better to consider this issue in clinical evaluations.

Keywords:

Helicobacter pylori , Biopsy , Serology , Shahr e kord