Synthesis of silver nanoparticles by Galega officinalis and its hypoglycemic effects in type ۱ diabetic rats
عنوان مقاله: Synthesis of silver nanoparticles by Galega officinalis and its hypoglycemic effects in type ۱ diabetic rats
شناسه ملی مقاله: JR_NAMJ-8-4_003
منتشر شده در در سال 1400
شناسه ملی مقاله: JR_NAMJ-8-4_003
منتشر شده در در سال 1400
مشخصات نویسندگان مقاله:
Fariba Azimi - Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
Fariba Mahmoudi - Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
Farzaneh Mahmoudi - Department of chemistry, Shahid Beheshti University, G. C., Tehran, Iran
Mostafa Amini - Department of chemistry, Shahid Beheshti University, G. C., Tehran, Iran
خلاصه مقاله:
Fariba Azimi - Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
Fariba Mahmoudi - Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
Farzaneh Mahmoudi - Department of chemistry, Shahid Beheshti University, G. C., Tehran, Iran
Mostafa Amini - Department of chemistry, Shahid Beheshti University, G. C., Tehran, Iran
Objective(s): Diabetes is related with the higher blood levels of liver enzymes and inflammatory factors. Galega officinalis is used as a medicinal plant for treatment of diabetes traditionally. In this work, silver nanoparticles (Ag-NPs) were synthesized with green method using Galega officinalis extract.Materials and Methods: The synthesized green Ag-NPs were characterized completely. Intact or diabetic rats receieved intraperitoneal injection of saline or ۲/۵mg/Kg green synthesized Ag-NPs. Mean serum levels of glucose, hepatic enzymes and hematological parameter were determined. Gene expression of tumor necrotic factor alpha (TNF-α) was done by real-time PCR. Results: Synthesis of green synthesized Ag-NPs was confirmed by FT-IR, XRD and UV-vis analyses. The FESEM and TEM images showed spherical Ag-NPs with size of ۲۵ nm. The hypoglycemic influence of Ag-NPs using Galega officinalis extract is reported for the first time in this study. Blood concentration of liver enzymes, urea, glucose, white blood cells count and TNF-α mRNA levels in visceral adipose tissue significantly declined in diabetic rats receiving Ag-NPs.Conclusion: The synthesized Ag-NPs using Galega officinalis extract may improve complication of diabetes via preventing liver hepatocyte damage and reducing inflammatory factors.
کلمات کلیدی: Diabetes, Galega officinalis, Liver enzymes, Silver nanoparticle, TNF-α
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1280603/