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Title

Mesenchymal stem cells in cancer therapy; the art of harnessing a foe to a friend

مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 10
Year: 1400
COI: JR_IJBMS-24-10_001
Language: EnglishView: 71
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Authors

Mehdi Karimi-Shahri - Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
Hossein Javid - Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Alireza Sharbaf Mashhad - Department of Medical Laboratory Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
Shaghayegh Yazdani - Department of Medical Laboratory Sciences, Ilam Institute for Medical Sciences, Ilam, Iran
Seyed Isaac Hashemy - Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of ‎Medical Sciences, Mashhad, Iran

Abstract:

For a long time, mesenchymal stem cells (MSCs) were discussed only as stem cells which could give rise to different types of cells. However, when it became clear that their presence in the tumor microenvironment (TME) was like a green light for tumorigenesis, they emerged from the ashes. This review was arranged to provide a comprehensive and precise description of MSCs’ role in regulating tumorigenesis and to discuss the dark and the bright sides of cancer treatment strategies using MSCs.To gather the details about MSCs, we made an intensive literature review using keywords, including MSCs, tumor microenvironment, tumorigenesis, and targeted therapy. Through transferring cytokines, growth factors, and microRNAs, MSCs maintain the cancer stem cell population, increase angiogenesis, provide a facility for cancer metastasis, and shut down the anti-tumor activity of the immune system. Although MSCs progress tumorigenesis, there is a consensus that these cells could be used as a vehicle to transfer anti-cancer agents into the tumor milieu. This feature opened a new chapter in MSCs biology, this time from the therapeutic perspective. Although the data are not sufficient, the advent of new genetic engineering methods might make it possible to engage these cells as Trojan horses to eliminate the malignant population. So many years of investigation showed that MSCs are an important group of cells, residing in the TME, studying the function of which not only could add a delicate series of information to the process of tumorigenesis but also could revolutionize cancer treatment strategies.

Keywords:

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This Paper COI Code is JR_IJBMS-24-10_001. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Karimi-Shahri, Mehdi and Javid, Hossein and Sharbaf Mashhad, Alireza and Yazdani, Shaghayegh and Hashemy, Seyed Isaac,1400,Mesenchymal stem cells in cancer therapy; the art of harnessing a foe to a friend,https://civilica.com/doc/1280661

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