Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Dimethylaminoparthenolide (DMAPT) as an alternative approach for treatment of Familial Mediterranean Fever (FMF)

مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 10
Year: 1400
COI: JR_IJBMS-24-10_013
Language: EnglishView: 134
This Paper With 7 Page And PDF Format Ready To Download

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 7 صفحه است به صورت فایل PDF در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Ali Mosayebian - Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Roya Sherkat - Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Saeid Abediankenari - Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of medical sciences, Sari, Iran
Monireh Golpour - Molecular and Cell Biology Research Center, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran
Alireza Rafiei - Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract:

Objective(s): Familial Mediterranean Fever (FMF) is a hereditary auto-inflammatory disorder that is caused by mutations in the Mediterranean fever (MEFV) gene and is associated with an increase in pro-inflammatory cytokines, such as interleukin-۱β (IL-۱β) and interleukin-۱۸ (IL-۱۸), leading to excess inflammation. Colchicine is a common drug widely used for treatment of FMF attacks, but about ۵–۱۵% of the patients show resistance to the regular colchicine treatment. In this study, we used dimethylamino-parthenolide (DMAPT), as a small molecule inhibitor of Nuclear factor-κB (NF-κB), NLR family Pyrin domain containing ۳ (NLRP۳), and cysteine-aspartic acid protease ۱(Caspase-۱) on FMF-derived peripheral blood mononuclear cells (PBMCs).Materials and Methods: The effects of DMAPT and colchicine on metabolic activity and apoptosis of FMF-derived PBMCs were evaluated by MTT and Annexin V/PI assays, respectively. Also, the expression levels of NF-κB, NLRP۳, MEFV, CASP۱, and IL-۱β mRNA were investigated using a TaqMan real-time PCR, and the protein levels of IL-۱β, IL-۱۸, and IL-۳۷ were assessed via an enzyme-linked immunosorbent assay (ELISA) in LPS/ ATP-stimulated PBMCs.Results: DMAPT decreased the expression levels of NFκB (۰.۳۸±۰.۰۹۶, P<۰.۰۰۰۱), NLRP۳ (۰.۳۹±۰.۱۲, P<۰.۰۰۱), MEFV (۰.۳۸۴±۰.۱۴۵, P<۰.۰۰۱), CASP۱ (۰.۴۸±۰.۱۳, P=۰.۰۰۲۳), and IL-۱β (۰.۰۹±۰.۰۹, P<۰.۰۰۰۱) and reduced the secretion levels of IL-۱β (۸.۹۲±۵.۳ vs. ۱۴۹.۸۵±۲۰.۹۲, P<۰.۰۰۰۱), IL-۱۸ (۱۳۵±۳۲.۱ vs. ۱۹۲±۲۲.۱۸, P=۰.۰۱), and IL-۳۷ (۲۷.۵±۶.۳ vs. ۷۸.۱۹±۱۴.۳, P<۰.۰۰۰۱) as compared to untreated cells.Conclusion: Given the obtained results in comparison with previous research, the future clinical development of DMAPT could result in the expansion of new anti-inflammatory therapeutics for FMF disorder.

Keywords:

Paper COI Code

This Paper COI Code is JR_IJBMS-24-10_013. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1280673/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Mosayebian, Ali and Sherkat, Roya and Abediankenari, Saeid and Golpour, Monireh and Rafiei, Alireza,1400,Dimethylaminoparthenolide (DMAPT) as an alternative approach for treatment of Familial Mediterranean Fever (FMF),https://civilica.com/doc/1280673

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :

  • Azizi G, Azarian SK, Nazeri S, Mosayebian A, Ghiasy S, ...
  • Abolhassani H, Kiaee F, Tavakol M, Chavoshzadeh Z, Mahdaviani SA, ...
  • Portincasa P. Colchicine, biologic agents and more for the treatment ...
  • Van Gorp H, Saavedra PH, de Vasconcelos NM, Van Opdenbosch ...
  • Goulielmos G, Fragouli E, Aksentijevich I, Sidiropoulos P, Boumpas D, ...
  • Majeed HA, El-Khateeb M, El-Shanti H, Rabaiha ZA, Tayeh M, ...
  • Medlej-Hashim M, Serre J-L, Corbani S, Saab O, Jalkh N, ...
  • Lee JH, Kim JH, Shim JO, Lee KC, Lee JW, ...
  • Corsia A, Georgin-Lavialle S, Hentgen V, Hachulla E, Grateau G, ...
  • Slobodnick A, Shah B, Pillinger MH, Krasnokutsky S. Colchicine: Old ...
  • Twig G, Livneh A, Vivante A, Afek A, Shamiss A, ...
  • Ter Haar N, Lachmann H, Özen S, Woo P, Uziel ...
  • Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, ...
  • Yang W-S, Xin Y, Sun S, Li X-M. The role ...
  • D’Anneo A, Carlisi D, Lauricella M, Emanuele S, Di Fiore ...
  • Baldwin AG, Brough D, Freeman S. Inhibiting the inflammasome: A ...
  • Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, ...
  • Fattahi S, Langroudi MP, Samadani AA, Nikbakhsh N, Asouri M, ...
  • Li S, Gao X, Wu X, Wu Z, Cheng L, ...
  • Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, ...
  • Jamilloux Y, Lefeuvre L, Magnotti F, Martin A, Benezech S, ...
  • Bren GD, Solan NJ, Miyoshi H, Pennington KN, Pobst LJ, ...
  • Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, ...
  • Flores-Lopez G, Moreno-Lorenzana D, Ayala-Sanchez M, Aviles-Vazquez S, Torres-Martinez H, ...
  • Yip-Schneider MT, Wu H, Stantz K, Agaram N, Crooks PA, ...
  • Zhang M, Liu R-T, Zhang P, Zhang N, Yang C-L, ...
  • Yip-Schneider MT, Wu H, Njoku V, Ralstin M, Holcomb B, ...
  • Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, ...
  • Kim SL, Liu YC, Seo SY, Kim SH, Kim IH, ...
  • Viennois E, Xiao B, Ayyadurai S, Wang L, Wang PG, ...
  • de Carvalho LSA, Fontes LBA, Gazolla MC, dos Santos Dias ...

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 2,034
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support