Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-24-10_015

تاریخ نمایه سازی: 11 مهر 1400

Abstract:

Objective(s): To investigate the potential therapeutic effect of Bougainvillea spectabilis flower decoction on aluminum chloride (AlCl۳)-induced neurotoxicity. Materials and Methods: Rats received daily intraperitoneal injections of AlCl۳ at ۱۰ mg/kg for two months and were treated with B. spectabilis decoction at ۵۰ or ۱۰۰ mg/kg or saline during the ۲nd month of the study. The control group received saline. Brain malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), acetylcholinesterase (AChE), amyloid Aβ peptide, and interleukin-۶ (IL-۶) concentrations and paraoxonase-۱ (PON-۱) activity were determined and brain histology was done. Behavioral and neurological testing included Morris water maze (WMZ), Y maze, and wire hanging. Results: Compared with saline controls, AlCl۳ significantly increased brain MDA and NO along with decreased GSH and PON-۱ activity. It also increased AChE, IL-۶, and amyloid Aβ concentrations. AlCl۳ impaired motor strength and memory performance and caused brain neurodegeneration. B. spectabilis decoction given at ۵۰ or ۱۰۰ mg/kg protected against the biochemical and histopathological alterations evoked by AlCl۳ by alleviating the increase in MDA and NO, and decrease in GSH and PON-۱ activity.  B. spectabilis decoction showed no significant effect on AChE but markedly decreased IL-۶ and amyloid Aβ in the brain of AlCl۳-treated rats. It also restored memory performance and motor strength, and protected against AlCl۳-induced neurodegeneration.Conclusion: These results suggest that B. spectabilis flower decoction might prove of value in the treatment of Alzheimer’s disease.

Authors

Omar Abdel-Salam

Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt

Marwa El-Shamarka

Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt

Eman Youness

Department of Medical Biochemistry, National Research Centre, Cairo, Egypt

Nermeen Shaffie

Department of Pathology, National Research Centre, Cairo, Egypt

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