Frequency and Antibiotic Resistance of Hybrid Entroaggregative/Uropathogenic Escherichia coli Isolated from Patients Hospitalized in Isfahan, Iran
Publish place: Infection Epidemiology and Microbiology، Vol: 7، Issue: 3
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IEM-7-3_002
تاریخ نمایه سازی: 11 مهر 1400
Abstract:
Backgrounds: This study aimed to analyse hybrid Entroaggregative/Uropathogenic Escherichia coli (EAEC/UPEC) isolates. To do so, the antibiotic resistance pattern and virulence genes were investigated in E. coli strains isolated from clinical specimens of patients hospitalized in Isfahan, Iran.
Materials & Methods: Disc diffusion method was used to determine the antibiotic susceptibility pattern of EAEC/UPEC isolates. Also, virulence determinants of these isolates were determinated by singleplex and multiplex PCR.
Findings: Overall, a total of ۱۴۸ E. coli isolates were collected, of which ۱۲ (۸.۱%) isolates were hybrid EAEC/UPEC strains, then antibiotic susceptibility examination was operated on these strains. The higest antibiotic resistance rate was related to ofloxacin (۴۲%), followed by trimethoprim-sulfamethoxazole (۴۱%), ceftriaxone and cefepime (۳۳%), and cefoxitin (۱۷%). All the isolates showed susceptibility to fosfomycin.
Conclusion: According to the current study, since resistance to fluoroquinolones has increased in hybrid strains, monitoring the drug susceptibility of hybrid strains seems critical in Iran. Fosfomycin is considered to be the drug of choise for infections caused by multidrug-resistant (MDR) Gram-positive and Gram-negative bacteria. Fortunately, ۱۰۰% of the strains were sensitive to fosfomycin.
Authors
Tahere Alipour
Department of Bacteriology and Virology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Sorour Farzi
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
Amir Emamie
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Atieh Darbandi
Department of Microbiology, School of Medicine and Microbial Biotechnology Research Centre, Iran University of Medical Sciences, Shahid Hemmat Highway, Tehran, Iran.
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