Synthesis of Some New ۸-Caffeinyl Chalcone Hybrid Derivatives as Potential Chemotherapeutic Agents

In this paper the design and synthesis of some novel ۸-caffeinyl chalcone hybrid derivatives as potential and promising bioactive compounds has been described. These compounds were acquired by coupling of synthesized hydroxyl chalcons and already synthesized ۸-bromocaffeine (۸-BC). The preparation of chalcones was performed from ۴-hydroxy acetophenone and/or ۴-hydroxy benzaldehyde with miscellaneous aromatic aldehydes and ketones through classic Claisen Schmidt condensation, respectively. The ۸-BC was obtained via bromination of caffeine using NBS and finally good to excellent of titles compounds were attained through SNAr-type reaction of ۸-BC and hydroxychalcones in the presence of efficient base in DMF

Keywords:

Hybrid Molecule , Caffeine , Chalcone , ۸-BC , ketone , aldehyde