Synthesis of Some New ۸-Caffeinyl Chalcone Hybrid Derivatives as Potential Chemotherapeutic Agents
عنوان مقاله: Synthesis of Some New ۸-Caffeinyl Chalcone Hybrid Derivatives as Potential Chemotherapeutic Agents
شناسه ملی مقاله: ICCNRT04_004
منتشر شده در چهارمین کنگره ملی شیمی و نانوشیمی از پژوهش تا فناوری در سال 1400
شناسه ملی مقاله: ICCNRT04_004
منتشر شده در چهارمین کنگره ملی شیمی و نانوشیمی از پژوهش تا فناوری در سال 1400
مشخصات نویسندگان مقاله:
Maede Chaharbaghi - Medicinal Chemistry Research Laboratory, Shiraz University of Technology, Shiraz, ۷۱۵۵۷-۱۳۸۷۶, Iran
Mohammad Navid Soltani Rad - Medicinal Chemistry Research Laboratory, Shiraz University of Technology, Shiraz, ۷۱۵۵۷-۱۳۸۷۶, Iran
خلاصه مقاله:
Maede Chaharbaghi - Medicinal Chemistry Research Laboratory, Shiraz University of Technology, Shiraz, ۷۱۵۵۷-۱۳۸۷۶, Iran
Mohammad Navid Soltani Rad - Medicinal Chemistry Research Laboratory, Shiraz University of Technology, Shiraz, ۷۱۵۵۷-۱۳۸۷۶, Iran
In this paper the design and synthesis of some novel ۸-caffeinyl chalcone hybrid derivatives as potential and promising bioactive compounds has been described. These compounds were acquired by coupling of synthesized hydroxyl chalcons and already synthesized ۸-bromocaffeine (۸-BC). The preparation of chalcones was performed from ۴-hydroxy acetophenone and/or ۴-hydroxy benzaldehyde with miscellaneous aromatic aldehydes and ketones through classic Claisen Schmidt condensation, respectively. The ۸-BC was obtained via bromination of caffeine using NBS and finally good to excellent of titles compounds were attained through SNAr-type reaction of ۸-BC and hydroxychalcones in the presence of efficient base in DMF
کلمات کلیدی: Hybrid Molecule, Caffeine, Chalcone, ۸-BC, ketone, aldehyde
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1290166/