Green Synthesis of Fe۳O۴/Ag nanocomposites by Saponins Tri Pterpenoid Extract and Evaluation of its application for drug delivery

Green synthesized of nanoparticles eliminate the need for a stabilizing and capping agent and show shape and size dependent biological activities. Biomolecules in the plant extract are involved in reduction of metal ions to nanoparticle in a one-step and eco-friendly synthesis process. Natural plant extracts contain wide range of metabolites including carbohydrates, alkaloids, phenolic compounds, and enzymes. The combination of Fe۳O۴ NPs and Ag NPs for drug delivery applications. Fe۳O۴/Ag nanocomposites can be synthesized through a green route using natural reagents, as both reducing and capping agent, minimizing the nanomaterial toxicity. Successful characterization of synthesized nanoparticles was done by XRD, FE-SEM and FT-IR analyses. The cytotoxicity of Fe۳O۴/Ag NPs was verified against PC۱۲ cells lines.

Keywords:

Green synthesis , Saponins tri pterpenoid extract , Ag nanoparticles , Fe۳O۴ nanoparticles , drug delivery , MTT assay