Secondary metabolite genome annotation for a new Nonomuraea sp.

Secondary metabolites produced by microorganisms include pigments, pharmaceutics, growth hormones, and other products which have been demonstrated to be useful in human health and industry (Singh et al., ۲۰۱۹). Actinobacteria are one of the most important bacteria used in industrial production of various secondary metabolites that retain them among leading candidates in the drug discovery pipelines (O'Brien and Wright, ۲۰۱۱). Studies on the bacterial genomes have demonstrated that they have much more potential for producing secondary metabolites than what is perceived in laboratories (Schorn et al., ۲۰۱۶). Nonomuraea is a rare actinomycete genus that is recognized as a promising resource for novel bioactive compounds (Sungthong and Nakaew, ۲۰۱۵). One of the most used tools for secondary metabolite gene clusters annotation is antiSMASH, which is an analysis shell for antibiotics and other secondary metabolites to identify secondary metabolites Biosynthetic Gene Clusters (BGCs) in three groups of bacteria, fungi, and plants (Blin et al., ۲۰۱۹). Finding such novel clusters in newly identified strains will open new opportunities for production of its valuable products with multidisciplinary usages.

Keywords:

Actinobacteria , Nonomuraea , Secondary metabolites , Functional annotation , Gene clusters