In silico analysis to predict involving pathways of transcribed ultraconserved regions (T-UCRs) in the bladder cancer

The transcribed ultraconserved regions (T-UCRs) are noncoding RNAs that are nearly ۱۰۰% conserved between the genome of three species: human rat and mouse. Selective conservation of these sequences during evolution suggests that these areas are important and necessary elements for proper cell function (Bejerano et al. ۲۰۰۴). UCRs are often located in the fragile sites and cancer-associated genomic regions. Therefore, it is suggested that these regions may be candidate genes for cancer susceptibility (Calin et al. ۲۰۰۷). Although more studies show that expression profile of T-UCRs alter in a variety of human carcinomas, however, their precise mechanism of action in tumorigenesis remains poorly understood. Here, we aim to investigate the expression profile alterations and putative functions of all T-UCRs in the bladder cancer (BlC).

Keywords:

Bladder cancer , The transcribed ultraconserved regions (T-UCRs) , long non-coding RNAs , Microarray analysis