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Title

Genome-scale Constraint-based Metabolic Modelling of Propionibacterium freudenreichii

Year: 1400
COI: ICSB04_067
Language: EnglishView: 38
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Authors

Mahsa Razavi - Iranian Institute of New-founded Sciences (IINS; MAANA);
Meysam Mobasheri - Iranian Institute of New-founded Sciences (IINS; MAANA); Department of Biotechnology, Islamic Azad University-Pharmaceutical Branch

Abstract:

Propionibacterium is an anaerobic bacterial genus with the history of use in manufacturing of Swiss cheese and more recently value-added bioproducts. While the use of this strain as microbial cell factory for production of vitamin B۱۲ has gained a growing interest, the industrial application of the strain requires improved yield and productivity of the target product. Systems modeling and analysis of the metabolic network is now being widely leveraged to gain holistic insights into the metabolic features of the biotechnologically important strains and devising bioengineering and culture optimization strategies for economically viable bioprocesses development. In the present study, a high-quality genome-scale metabolic model of P. freudenreichii ssp. freudenreichii strain DSM ۲۰۲۷۱ is developed and validated. The model was then analyzed using the state-of-the-art systems biology methods to uncover the metabolic capabilities of this strain.

Keywords:

Paper COI Code

This Paper COI Code is ICSB04_067. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1290932/

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Razavi, Mahsa and Mobasheri, Meysam,1400,Genome-scale Constraint-based Metabolic Modelling of Propionibacterium freudenreichii,The 4th Iranian Conference on Systems Biology,Tehran,https://civilica.com/doc/1290932

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