Relationship Between Adenosine Deaminase with Ectopic Pregnancy in Pregnant Women Referred to Motahari Hospital in Urmia (۲۰۱۷-۲۰۱۸)

Background and Objective: One of the most common causes of maternal mortality in the first trimester of pregnancy is ectopic pregnancy (EP). Adenosine de­aminase (ADA) plays an essential role in production, maturation and function of lymphoid cells, which is produced in all tissues of the body. Total serum adenosine deaminase levels decrease during normal pregnancy. Considering the importance of early detection of EP, this study aimed to investigate the relationship between adenosine deaminase and EP in pregnant women referred to Motahari Hospital in Urmia from ۲۰۱۷ to ۲۰۱۸. Material and Methods: This study consisted of two groups of patients including patients with EP as a case group and patients with normal pregnancy confirmed by sonography as a control group. The level of βHCG and serum ADA levels were compared in the two groups. P-values less than ۰.۰۵ were considered as significant. Results: In this study, ۹۴ pregnant women were enrolled, including ۴۷ patients as control group with normal pregnancy and ۴۷ patients as case group with EP. The mean ADA level in patients with EP and the control group were ۱۲.۲۱±۸.۱۷ IU/L and ۸.۴۴±۶.۲۱ IU/L (P=۰.۰۱), respectively. The mean βHCG level in women with EP was ۳۲۱۵.۶۰±۱۴۰۰.۷۱ mIU/mL. In women with normal pregnancy, it was ۱۱۹۲۶.۹۶±۳۴۰۸.۲۳ mIU/mL (P=۰.۰۰۱). Conclusion: High levels of ADA can be helpful in the early diagnosis of EP.

Keywords:

: Ectopic pregnancy , Adenosine deaminase , early diagnosis of Ectopic pregnancy , lymphoid cell