Zahra Akbarian Rad - Department of Pediatrics, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Shahla Yazdani - Department of Obstetrics and Gynecology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Mina Galeshi - Shahroud University of Medical Sciences, Iran
Neda Eftekhari - Department of Obstetrics and Gynecology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Fatemeh Shafizadeh - Department of Obstetrics and Gynecology, School of Medicine, Babol University of Medical Sciences, Babol, IR Iran

Background & Objective: Premature preterm rupture of membranes (PPROM) occurs in about ۲-۵% of singleton pregnancies and is known to cause one-third of preterm births. Our primary aim was to determine the maternal and neonatal outcomes in PPROM cases in mothers with a gestational age of less than ۳۷ weeks. Methods: In this prospective cross-sectional study, eligible singleton women between ۲۴+۰-۳۷+۶ weeks of gestation with the PPROM enrolled who had referred to Ayatollah Rouhani Hospital in Babol, Iran, during the years ۲۰۱۹-۲۰۲۰. Maternal and neonatal outcomes were obtained by the checklist. Results: The mean age of the studied mothers was ۲۹.۳± ۶.۱۹ years, and their mean body mass index was ۳۰.۶ ±۵. The incidence of chorioamnionitis at the gestational age of >۳۲ weeks was more than that in women at gestational age equal to or over ۳۲ weeks (P≤۰.۰۰۰۱). Vaginal bleeding was almost more than twice as high in women with a gestational age of less than ۳۲ weeks compared to those with a gestational age equal to or over ۳۲ weeks (P≤۰.۰۰۰۱). Neonatal morbidity was higher in all cases at less than ۳۲ weeks of gestation (P≤۰.۰۰۰۱). The neonatal mortality rate was ۵.۳۵%, but it was ۲۵% at less than ۳۲ weeks of gestation (P≤۰.۰۰۰۱). The latency period greater than ۷ days had more odds ratio for neonatal morbidity. Conclusion: Due to the high incidence of maternal and neonatal outcomes in gestational age less than ۳۲ weeks, it is suggested that appropriate instructional materials and proper proceeding should be taken to prevent preterm labor and preterm rupture of the membranes.

Latency, Morbidity, Neonatal mortality, Preterm labor, Premature rupture of membranes