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Title

Effect of Particle Size, Compaction Force and Presence of Aerosil ۲۰۰ on the Properties of Matrices Prepared from Physical Mixture of Propranolol Hydrochloride and Eudragit RS or RL

Year: 1386
COI: JR_IJBMS-10-3_008
Language: EnglishView: 66
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Authors

Fatemeh Sadeghi - Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Research Center, Mashhad University of Medical sciences, Mashhad, Iran
Fatemeh Mosaffa - School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Hadi Afrasiabi Garekani - Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Research Center, Mashhad University of Medical sciences, Mashhad, Iran

Abstract:

Objective Eudragits are widely used polymers in the production of oral sustained release dosage forms. The application of these polymers in the production of inert insoluble matrices has been investigated. However the effect of particle size, compaction force and presence of Aerosil ۲۰۰ as a glidant on the properties of Eudragit RS and RL matrices prepared by direct compression of their physical mixtures with drug have not been fully investigated. This study was performed in order to investigate the effect of above mentioned factors on physicomechanical and release properties of propranolol hydrochloride and Eudragit RS or RL matrices. Materials and Methods Polymers were separated to different size fractions using series of sieves. Matrices were prepared in ۱:۳ ratio by direct compression of physical mixture of drug and polymer. To study the effect of Aerosil ۲۰۰, matrices were prepared from different size fractions containing ۱%w/w Aerosil ۲۰۰. To investigate the effect of compaction force, the ۱۲۵-۱۷۷µm size fraction of polymer was chosen and compression carried out at ۵, ۱۰, ۱۵, ۲۰ and ۳۰ kN compaction force. Matrices were characterized for their hardness and dissolution. Results The results showed that due to decrease in tablet hardness the release rate increased with increase in polymer particle size. Drug release rates were almost the same for both polymers at similar particle size range. The same trend was also observed for matrices containing Aerosil ۲۰۰. Addition of Aerosil ۲۰۰ decreased the rate of drug release from all matrices except those prepared from ۲۵۰-۳۵۰ µm size fraction. This was attributed to increase in the tablet hardness. Increase in compaction force from ۵kN to ۲۰kN increased the tablet hardness and consequently decreased the release rate, however, further increase in compaction force from ۲۰ to ۳۰ kN did not significantly affect the release rates of drug. Conclusion Polymer particle size, presence of Aerosil and compaction force are important factors affecting drug release from Eudragit RS or RL matrices. Eudragit RS and RL polymers alone are not suitable for preparation of sustained release matrices containing water soluble drugs.

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This Paper COI Code is JR_IJBMS-10-3_008. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1295261/

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Sadeghi, Fatemeh and Mosaffa, Fatemeh and Afrasiabi Garekani, Hadi,1386,Effect of Particle Size, Compaction Force and Presence of Aerosil ۲۰۰ on the Properties of Matrices Prepared from Physical Mixture of Propranolol Hydrochloride and Eudragit RS or RL,https://civilica.com/doc/1295261

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