An Investigation of the Relationship between Serum Vitamin E Status and Coronary Risk Factors in Dyslipidaemic Patients

Objective Vitamin E is a major lipid-soluble antioxidant. It has been demonstrated that vitamin E supplementation has a beneficial effect against coronary heart disease (CHD). This study to investigate the effects of coronary risk factors on serum vitamin E status in patients with dyslipidaemia. Materials and Methods This tertiary care hospital; case - control study was comprised ۲۳۷ dyslipidaemic patients and ۱۳۵ healthy individuals recruited from university and hospital employees. Serum vitamin E concentration was measured using high performance liquid chromatography (HPLC). Results Compared to the healthy individuals, the dyslipidaemic patients had higher serum vitamin E (p<۰.۰۰۱), but serum vitamin E / total cholesterol ratio did not differ between patients and healthy controls (p>۰.۰۵). Serum vitamin E did not differ between subcategories of dyslipidaemic patients with and without coronary risk factors (p>۰.۰۵), but Serum vitamin E / total cholesterol ratio was higher in patients with established coronary heart disease (p<۰.۰۱), hypertriglyceridaemia (p<۰.۰۵) and metabolic syndrome (p<۰.۰۵). In the patients there was not a strong association between serum vitamin E or serum vitamin E / total cholesterol ratio and coronary risk factors except for the serum cholesterol. Conclusion Serum vitamin E or vitamin E / total cholesterol ratio is not associated with the risk of coronary heart disease. Therefore, higher serum vitamin E or vitamin E / total cholesterol ratio doesn’t seem to have a preventive role against coronary heart disease.

Keywords:

Cholesterol , Coronary Heart Disease , Dyslipidaemia , metabolic syndrome , Multiple regression analysis , Vitamin E