Trans-chalcone enhances insulin sensitivity through the miR-۳۴a/SIRT۱ pathway
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 21، Issue: 4
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
View: 197
This Paper With 5 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
این Paper در بخشهای موضوعی زیر دسته بندی شده است:
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-21-4_002
تاریخ نمایه سازی: 27 مهر 1400
Abstract:
Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin ۱ (SIRT۱) as a direct target of miR-۳۴a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of trans-chalcone on the miR-۳۴a/SIRT۱ pathway as a possible mechanism for its hypoglycemic and hypoinsulinemic effects. Materials and Methods: In this study, thirty male rats were randomly divided into three groups (n=۱۰): solvent control (NS), oral administration of trans-chalcone for ۲ (N۲T) and ۶ weeks (N۶T) groups. Then, hepatic levels of miR-۳۴a and SIRT۱ were measured through the qRT-PCR method.Results: Trans-chalcone reduced food intake, body weight gain, and serum glucose as well as insulin levels. Also, this chalcone inhibited hepatic miR-۳۴a expression and significantly elevated SIRT۱ mRNA level. Conclusion: Trans-chalcone as an insulin-sensitizing chalcone partly acts through the miR-۳۴a/SIRT۱ pathway.
Keywords:
Authors
Elham Karimi Sales
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Sajad Jeddi
Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abbas Ebrahimi-Kalan
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Reza Alipour
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :