Trans-chalcone enhances insulin sensitivity through the miR-۳۴a/SIRT۱ pathway

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-21-4_002

تاریخ نمایه سازی: 27 مهر 1400

Abstract:

Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin ۱ (SIRT۱) as a direct target of miR-۳۴a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of trans-chalcone on the miR-۳۴a/SIRT۱ pathway as a possible mechanism for its hypoglycemic and hypoinsulinemic effects. Materials and Methods: In this study, thirty male rats were randomly divided into three groups (n=۱۰): solvent control (NS), oral administration of trans-chalcone for ۲ (N۲T) and ۶ weeks (N۶T) groups. Then, hepatic levels of miR-۳۴a and SIRT۱ were measured through the qRT-PCR method.Results: Trans-chalcone reduced food intake, body weight gain, and serum glucose as well as insulin levels. Also, this chalcone inhibited hepatic miR-۳۴a expression and significantly elevated SIRT۱ mRNA level. Conclusion: Trans-chalcone as an insulin-sensitizing chalcone partly acts through the miR-۳۴a/SIRT۱ pathway.

Authors

Elham Karimi Sales

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Sajad Jeddi

Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abbas Ebrahimi-Kalan

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Mohammad Reza Alipour

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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