Deep brain stimulation in a rat model of post-traumatic stress disorder modifies forebrain neuronal activity and serum corticosterone

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-21-4_004

تاریخ نمایه سازی: 27 مهر 1400

Abstract:

Objective(s): Post-traumatic stress disorder (PTSD), one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event followed by intense fear. In rats with contextual fear conditioning (CFC), a model of PTSD caused by CFC (electrical foot shock chamber), deep brain stimulation (DBS) alleviates CFC abnormalities.Materials and Methods: Forty Male Wistar rats (۲۲۰–۲۵۰ g) were divided into ۵ groups (n=۸) and underwent stereotactic surgery to implant electrodes in the right basolateral nucleus of the amygdala (BLn). After ۷ days, some animals received a foot shock, followed by another ۷-day treatment schedule (DBS treatment). Next, freezing behavior was measured as a predicted response in the absence of the foot shock (re-exposure time). Blood serum corticosterone levels and amygdala c-Fos protein expression were assessed using Enzyme-linked immunosorbent assay (ELISA) and Western blot, respectively. Furthermore, freezing behaviors by re-exposure time test and general anxiety by elevated plus-maze (EPM) were evaluated. Results: PTSD decreased serum corticosterone levels and increased both amygdala c-Fos expression and freezing behaviors. Therefore, DBS treatment significantly (P<۰.۰۰۱) enhanced serum corticosterone levels and could significantly (P<۰.۰۰۱) reduce both c-Fos protein expression and freezing behaviors’ duration. However, DBS treatment has no effect on the general anxiety in PTSD rats.Conclusion: We argue that these outcomes might demonstrate the mechanism of DBS treatment, a complete therapeutic strategy, in PTSD patients.

Authors

Mina Mokhtari hashtjini

Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

Gila Pirzad Jahromi

Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran

Seyed Shahabeddin sadr

Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

Gholam Hossein Meftahi

Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran

Boshra Hatef

Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran

Danial Javidnazar

Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

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