Samad Akbarzadeh - Departments of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Hossein Gholampour - The Student’s Committee Research, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Parviz Farzadinia - Departments of Anatomy, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Adel Daneshi - The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
Bahman Ramavandi - Departments of Environmental Health Engineering, Faculty of Health, Bushehr University of Medical Sciences, Bushehr, Iran
Ali Moazzeni - Departments of Hematology, Faculty of Allied Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Mojtaba Keshavarz - Departments of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Afshar Bargahi - Departments of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

Objective(s): Diabetes is a metabolic syndrome which is associated with the worldwide major public health problems. There are many natural compounds from the sea-market, as a valuable aquatic source, along with the variety of health and therapeutic benefits. In the present research, with respect to the traditional and ethnic uses of Sargassum oligocystum algae for healing of some diseases which have similar metabolic mechanism to the diabetes, its anti-diabetic effects in animal model was proposed. Materials and Methods: The animals (rat) were divided into the normal control, diabetic control, positive control and, the test groups. The test groups were gavaged with oral doses of ۱۵۰ and ۳۰۰ mg/kg of algae hydroalcoholic extracts. After ۳۰ days of intervention the serum glucose, cholesterol, triglyceride, HDLC, LDLC, insulin, insulin resistance, β-cells function and, the histopathology of pancreatic tissue were evaluated. Results: In animals that were fed with algae extracts a significant decrease in the fasting blood glucose, triglyceride and HOMA-IR and an increase in the HOMA-B with no significant impacts on the insulin, cholesterol and HDL were observed. Also, the histopathology evaluations in the groups which were treated with algae extract revealed the regeneration and reconstitution of damaged pancreatic β-cells. Conclusion: The results give evidence that, the S. oligocystum algae extract has a healing effect on diabetes which can be considered as a new research prospect for the natural therapy of diabetes.

Cholesterol, HDL, HOMA-IR, HOMA-B, insulin resistance, Sargassum oligocystum