Effect of Meal Frequency on Human Serum Complements C۳ and C۴
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 11، Issue: 1
Publish Year: 1387
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-11-1_007
تاریخ نمایه سازی: 27 مهر 1400
Abstract:
Objective Despite numerous reports on the effects of meal frequency on biochemical parameters such as plasma lipid profile, glucose and insulin, there is almost no study to investigate the influence of meal frequency on immune system. In the present article, for the first time, the effect of meal frequency on complement components C۳ and C۴, as key components of the complement system, has been investigated. Materials and Methods The subjects of this study were fifteen healthy nonsmoker males aged ۲۷.۴±۶ years. All subjects were placed on two identical diets, in which they consumed the same food either as nine snacks at ۲ hrs intervals (nibbling diet) or three meals at ۷ hrs intervals (gorging diet). Each diet was continued for fourteen days. At the end of each program, a fasting blood sample was obtained and its complements C۳ and C۴ levels were determined. The results were compared using Student’s paired t-test. Results Nibbling diet led to a significant (P<۰.۰۵) decrease in the complement C۳ level compared to the normal dietary regimen (۱۱۱.۶±۳۴.۵ vs. ۱۴۰.۰±۲۷.۵ mg/dl). On the other hand, during gorging period, no significant change was observed in complement C۳ level compared with the control value ۱۴۵.۷±۵۱.۵ vs. ۱۴۰.۰±۲۷.۵ mg/dl). However, the level of complement C۴ increased significantly (P< ۰.۰۵) following gorging diet (۲۵.۶ ±۱۵.۵ vs. ۳۷.۶±۱۱.۵ mg/dl). Conclusion According to the results obtained, a change in the number of meals may alter the serum levels of complements C۳ and C۴ with a decrease in both complements levels and an increase in C۴ level during nibbling and gorging dietary regimens, respectively.
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Authors
Mohammad-Reza Rashidi
Biochemistry and Drug Metabolism Laboratory, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Badrossadat Rahnama
Immunology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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