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Bio-effectiveness of the main flavonoids of Achillea millefolium in the pathophysiology of neurodegenerative disorders- a review

Publish place: Iranian Journal of Basic Medical Sciences، Vol: 20، Issue: 6
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/1295704

شناسه ملی سند علمی:

JR_IJBMS-20-6_001

تاریخ نمایه سازی: 28 مهر 1400

Abstract:

The Achillea millefolium L. (Yarrow) is a common herb which is widely being used, worldwide. Achillea is being used for treatment of many disorders since centuries. It is considered safe for supplemental use and flavonoids such as kaempferol, luteolin and apigenin are of main constituents present in Achillea. Most of both antioxidant and anti-inflammatory properties of this herb have been attributed to its flavonoid content. Oxidative and inflammatory processes play important roles in pathogenesis of neurodegenerative diseases. Present review was aimed to review the latest literature evidences regarding application of Achillea and/or its three main flavonoid constituents on epilepsy, Alzheimer's disease, multiple sclerosis, Parkinson's disease and stroke.

Keywords:

Achillea millefolium , Flavonoids , Medicinal , Neurodegenerative disease , Plants

Authors

Fatemeh Ayoobi

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Ali Shamsizadeh

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Iman Fatemi

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Alireza Vakilian

Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mohammad Allahtavakoli

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Gholamhossein Hassanshahi

Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Amir Moghadam-Ahmadi

Department of Neurology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

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