Melatonin upregulates ErbB۱ and ErbB۴, two primary implantation receptors, in pre-implantation mouse embryos

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-20-6_007

تاریخ نمایه سازی: 28 مهر 1400

Abstract:

Objective(s): To evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB۱ and ErbB۴). Materials and Methods: Two-cell mouse embryos were cultured in ۳ groups: simple media, melatonin-treated (۱۰-۹ M melatonin) and Luzindole-treated (۱۰-۹ M luzindole). Then, the rate of ErbB۱ and ErbB۴ gene and protein expression, the level of intracellular ROS, antioxidant capacity, and also the number of cells were evaluated and compared with the fourth group in vivo developed blastocysts (control group). Results: We concluded that melatonin significantly up-regulated the ErbB۱ and ErbB۴ gene and protein expression, decreased intracellular ROS, increased the total antioxidant capacity, and also elevated the cell numbers in the melatonin-treated group compared with the other groups (P≤۰.۰۵). Conclusion: The use of melatonin may be a helpful factor in improving the embryo quality and enhancing the expression of ErbB۱ and ErbB۴, two important implantation-related genes and proteins.

Authors

Ghazaleh Moshkdanian

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Fatemeh Moghani-Ghoroghi

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Parichehr Pasbakhsh

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Seyed Noureddin Nematollahi-Mahani

Department of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Atefeh Najafi

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iranv

Iraj Ragerdi Kashani

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

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