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Title

Effect of rosiglitazone on amyloid precursor protein processing and Aβ clearance in streptozotocin-induced rat model of Alzheimer’s disease

Year: 1396
COI: JR_IJBMS-20-5_004
Language: EnglishView: 36
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Authors

Li Wang - Department of Geriatrics, the Second Affiliated Hospital of the Harbin Medical University, Harbin ۱۵۰۰۸۱, China
Wei Liu - Department of Neurology, Peking University Third Hospital, Beijing ۱۰۰۰۸۰, China
Ying Fan - Department of Geriatrics, the Second Affiliated Hospital of the Harbin Medical University, Harbin ۱۵۰۰۸۱, China
Tingting Liu - Department of Geriatrics, the Second Affiliated Hospital of the Harbin Medical University, Harbin ۱۵۰۰۸۱, China
Chunjiang Yu - Department of Neurology, The Second Affiliated Hospital of the Harbin Medical University, Harbin ۱۵۰۰۸۱, China

Abstract:

Objective(s): Increasing evidence suggests that Alzheimer’s disease (AD) is associated with diabetes. Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPAR-γ) agonist and anti-diabetic agent, may improve symptoms of AD. However, the underlying therapeutic potential of it has not been fully elucidated. Materials and Methods: Rats were divided into four groups: control group, sham operated group, Streptozotocin (STZ) group, rosiglitazone (RGZ) group. Particularly, the STZ-induced rat model was established by intracerebroventricular injection (۳ mg/kg) on the first and third day. The water maze behavioral test was performed to evaluate spatial reference learning and memory of the rats. Aβ۱-۴۰ and Aβ۱-۴۲ levels were measured by ELISA method. To determine APP-derived fragment, BACE۱ and Aβ degrading enzymes levels, such as NEP and IDE, as well as Aβ transportation protein level, such as LRP۱, RAGE, Abca۱ and APOE , which were analyzed by Western blot. Immunohistochemistry was used to observe the change of Aβ۱-۴۰ and Aβ۱-۴۲ in hippocampus. Results: Chronic treatment with RGZ could reduce the Aβ level and improved spatial memory performance in STZ-induced rat model. However, RGZ modified the expression of specific transport proteins monitoring Aβ clearance, such as ATP-binding cassette transporter ۱ (ABCA۱), lipoprotein receptor-related protein ۱ (LRP۱), and the advanced glycation end product-specific receptor (RAGE) rather than change levels of Aβ degrading enzymes, such as IDE and NEP, nor affect APP processing.  Conclusion: As a potential therapeutic strategy, rosiglitazone might exert anti-AD effect not by alteration of APP processing pathway and Aβ degradation directly, but through promotion of Aβ clearance indeed.

Keywords:

Alzheimer’s disease , Amyloid precursor protein processing , β-amyloid peptide clearance , Peroxisome proliferator activated receptor γ

Paper COI Code

This Paper COI Code is JR_IJBMS-20-5_004. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1295722/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Wang, Li and Liu, Wei and Fan, Ying and Liu, Tingting and Yu, Chunjiang,1396,Effect of rosiglitazone on amyloid precursor protein processing and Aβ clearance in streptozotocin-induced rat model of Alzheimer’s disease,https://civilica.com/doc/1295722

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  • ۱.Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, ...
  • ۲.Koldamova R, Fitz NF, Lefterov I. ATP-binding cassette transporter A۱: ...
  • ۳.Do TM, Dodacki A, Alata W, Calon F, Nicolic S, ...
  • ۴.Pahnke J, Langer O, Krohn M. Alzheimer's and ABC transportersnew ...
  • ۵.Kanekiyo T, Liu CC, Shinohara M, Li J, Bu G. ...
  • ۶.Provias J, Jeynes B. The role of the blood-brain barrier ...
  • ۷.Wang H, Chen F, Zhong KL, Tang SS, Hu M, ...
  • ۸.Cai Z, Liu N, Wang C, Qin B, Zhou Y, ...
  • ۹.Deane R, Singh I, Sagare AP, Bell RD, Ross NT, ...
  • ۱۰.Chakrabarti S, Khemka VK, Banerjee A, Chatterjee G, Ganguly A, ...
  • ۱۱.Park SJ, Kim YH, Nam GH, Choe SH, Lee SR, ...
  • ۱۲.Imfeld P, Bodmer M, Jick SS, Meier CR. Metformin, other ...
  • ۱۳.Heneka MT, Fink A, Doblhammer G. Effect of pioglitazone medication ...
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