The effect of caffeine on orthodontic tooth movement in rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 20، Issue: 3
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-20-3_005
تاریخ نمایه سازی: 28 مهر 1400
Abstract:
Objective(s): to determine the effect of different doses of caffeine on orthodontic tooth movement (OTM) in rats. Materials and Methods: Forty male ۲۵۰-۳۰۰ g Sprague-Dawley rats were randomly divided into four groups of ten animals each and received ۰ (control), ۱ g/l, ۲ g/l and ۳ g/l caffeine in tap water for ۳ days. Orthodontic appliances were ligated between the maxillary first molars and incisors on the ۴th day of the study period. All rats were sacrificed after ۲ weeks of treatment after which OTM was measured. Hematoxylin/eosin-stained sections of the molars were prepared and the mesial roots were examined for resorption-lacunae depth and osteoclast number. ANOVA was used for statistical analysis (P<۰.۰۵). Results: A significant decrease in OTM was observed only in the ۲ g/l (P=۰.۰۴۳) and ۳ g/l (P<۰.۰۱) caffeine-receiving rats compared to the control animals. Osteoclast counts and resorption-lacunae depths demonstrated significant differences between each of the caffeine groups and control rats (P<۰.۰۵). None of the variables showed significant differences between the caffeine groups (P>۰.۰۵). Conclusion: According to our findings, one of the effects of caffeine consumption during orthodontic treatment in rats was decreased root resorption. Additionally, concentrations of ۲ g/l and ۳ g/l inhibited OTM which seems to be due to its influence on osteoclast numbers.
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Authors
Mohsen Shirazi
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Hamed Vaziri
Private practice, Houston, Texas
Behzad Salari
Orthodontic Resident, Department of Orthodontics, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
Pouria Motahhari
Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran
Shahroo Etemad-Moghadam
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Ahmad Reza Dehpour
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
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