Antinociceptive Effect of Promethazine in Mice
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 12، Issue: 3
Publish Year: 1388
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-12-3_003
تاریخ نمایه سازی: 30 مهر 1400
Abstract:
Objective(s) The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. Materials and Methods Antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. Results Promethazine (۴ and ۶ mg/kg) and acetylsalicylic acid (۱۰۰ mg/kg) produced a significant inhibition of the second phase response in the formalin pain model (P<۰.۰۵) and the drug couldn’t show an antinociceptive effect in the first phase. Morphine (۱۰ mg/kg) inhibited both first and second phase response (P<۰.۰۱). Drug also showed a dose-dependent inhibition of acetic acid-induced abdominal writhes. The tail flick and hot plate latency weren’t different from control (P>۰.۰۵) and administration of naloxone (۰.۱ mg/kg) couldn't block the antinociceptive effect of promethazine. Conclusion The data obtained suggest that antinociceptive effects of the promethazine may be mediated via peripheral and not central mechanisms.
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Authors
Amir Farshchi
School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Golbarg Ghiasi
School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Peyman Malek Khatabi
School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Hosein Farzaee
School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Amin Niayesh
School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
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