Shokouhsadat Hamedi - Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Reza Shams-Ardakani - Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Omid Sadeghpour - Herbal Medicine Department, Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
Gholamreza Amin - Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Dawood Hajighasemali - Faculty of Traditional Medicine, Iran University of Medical Sciences, Tehran, Iran
Hossein Orafai - Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing ۷۰ mg stem bark extract of Ziziphus jujuba were formulated  by using Carbopol ۹۳۴, PVP k۳۰ and gelatin as polymers. Discs were made by granulation  and direct compression. Discs were standardized based on the total phenol.  Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out. Results: Discs showed excellent mucoadhesion and released high amount of the active ingredients (۴۷%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity. Conclusion:This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’t follow the fick’s law. The water uptake and dissolution (DS), increased with the passing of time.

Carbopol ۹۳۴, Mucoadhesive discs, Pharmaceutical tests, PVP(Polyvinylpyrrolidone), Ziziphus jujuba stem bark