Masoud Mobini - Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Maryam Mortazavi - Department of Gynecology and Obstetrics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Somayeh Nadi - Yadegar Emam Health Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Mohammad Zare-Bidaki - Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Somayeh Pourtalebi - Department of Microbiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Mohammad Kazemi Arababadi - Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-۱۰(IL-۱۰) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-۱۰ during pregnancy may result in several pathologic conditions such as preterm labor. IL-۱۰ leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK۱/STAT۳ pathway in the target cells. This review has collected recent data regarding the status of IL-۱۰ expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.

IL-۱۰, Preterm delivery, Term delivery