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Title

The Relationship between Vitamin D Deficiency and Increased Oxidative Stress in Patients with Colon Cancer

Year: 1400
COI: JR_ZUMS-29-137_007
Language: EnglishView: 59
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Authors

Hadis Musavi - Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Tayebeh Azramezani Kop - Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Anahita Ebrahimpour - Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Setareh Rezatabar - Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Afsaneh Dashtaki - Dept. of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Fatemeh Kalaki-Jouybari - Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Masoumeh Karimi - Dept.of Radiathion Oncology, Babol University of Medical Sciences, Babol, Iran
Sohrab Halalkhor - Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Abstract:

Background and Objective: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Oxidative stress is one of the involved factors in CRC onset and progression. Recent examinations have revealed antioxidant characteristics of vitamin D. Given the vital role of this vitamin in balancing free radicals and antioxidant capacity, in this study we intended to review the association between vitamin D deficiency and oxidative stress in CRC patients. Materials and Methods: In the present case-control study, ۳۰ CRC patients and ۳۲ healthy individuals were entered, based on the defined inclusion and exclusion criteria. Peripheral blood was taken from the subjects. Thiobarbituric acid reactive substance (TBARS) values, total antioxidant capacity, and serum vitamin D were measured. Data were interpreted using SPSS ۱۸ software; t-test and the Mann Whitney test were applied. Results: The outcomes explained that TBARS values were significantly greater in patients group (P <۰.۰۰۵), but no meaningful difference was monitored in the total antioxidant capacity. ۲۱ (۷۰%) patients and ۱۴ (۴۴%) control subjects had inadequate vitamin D. There was a significant association between serum vitamin D in both groups (P <۰.۰۰۵). A notable negative relationship was found between vitamin D values and oxidative stress indicator (p=۰.۰۵, r =-۰.۲۴۹). Conclusion: Insufficient vitamin D can lead to an increase in oxidative stress, which is directly associated with CRC. Serum vitamin D levels were also inadequate in high percentage of cancer patients. Given the predominance of vitamin D insufficiency in the population, more extensive studies are required to prove the impact of deficiency on disease pathogenesis.

Keywords:

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This Paper COI Code is JR_ZUMS-29-137_007. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1296125/

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Musavi, Hadis and Azramezani Kop, Tayebeh and Ebrahimpour, Anahita and Rezatabar, Setareh and Dashtaki, Afsaneh and Kalaki-Jouybari, Fatemeh and Karimi, Masoumeh and Halalkhor, Sohrab,1400,The Relationship between Vitamin D Deficiency and Increased Oxidative Stress in Patients with Colon Cancer,https://civilica.com/doc/1296125

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Type of center: علوم پزشکی
Paper count: 1,101
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