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Title

Protective effect of swimming and genistein on the expression of microRNA ۱۳۲, insulin growth factor ۱, and brain-derived neurotrophic factor genes, as well as spatial memory, in the hippocampus of diabetic ovariectomized rats

Year: 1400
COI: JR_AJNPP-8-4_003
Language: EnglishView: 79
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Authors

Shirin Babri - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Parisa Habibi - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Fatemeh Nouri - Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
Mehdi Khazaei - Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
Sepehr Nayebi Rad - Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Gonja Javani - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract:

Background and Objective: The present study aimed to assess the effects of the combined use of exercise and genistein on the hippocampal expression of microRNA-۱۳۲, IGF-۱, and BDNF in type ۲ diabetic ovariectomized rats. Materials and Methods: Wistar female rats in the weight range of ۱۸۰-۲۲۰ gr (n=۱۰) were assigned to six groups: sham, ovariectomy, ovariectomized diabetic, ovariectomized diabetic treated with genistein for eight weeks, diabetic ovariectomized treated with swimming for eight weeks, and a group that was treated with both genistein and swimming for eight weeks. The effect of those treatments was assessed by the determination of microRNA-۱۳۲, insulin growth factor ۱ (IGF-۱), and brain-derived neurotrophic factor (BDNF) expression levels within the hippocampus. These genes were evaluated by real-time-polymerase chain reaction (RT-PCR) and spatial memory was assessed by the Morris water maze. Results: Ovariectomy demonstrated a decrease in the expression of microRNA-۱۳۲, IGF-۱, and BDNF in the hippocampus, as well as spatial memory, in diabetic ovariectomized rats, which showed a  greater reduction in the expression of those genes in rats (P<۰.۰۵). Nevertheless, genistein administration, swimming training, and a combination of them significantly up-regulated microRNA-۱۳۲, BDNF, and IGF-۱ expression, as well as spatial memory (P<۰.۰۵). Conclusions: As evidenced by the obtained results, the combined use of genistein and swimming could prevent estrogen deficiency effects in the hippocampus of ovariectomized diabetic rats

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Paper COI Code

This Paper COI Code is JR_AJNPP-8-4_003. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1296166/

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Babri, Shirin and Habibi, Parisa and Nouri, Fatemeh and Khazaei, Mehdi and Nayebi Rad, Sepehr and Javani, Gonja,1400,Protective effect of swimming and genistein on the expression of microRNA ۱۳۲, insulin growth factor ۱, and brain-derived neurotrophic factor genes, as well as spatial memory, in the hippocampus of diabetic ovariectomized rats,https://civilica.com/doc/1296166

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Type of center: علوم پزشکی
Paper count: 3,547
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