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Title

The Effect of Phencyclidine New Derivatives on Anxiety Behaviors in Rats

Year: 1389
COI: JR_IJBMS-13-2_003
Language: EnglishView: 60
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Authors

Ramin Hajkhani - Department of Biology, Faculty of Sciences, Islamic Azad UniversityKaraj branch, Karaj, Iran
Jalal Solati - Department of Biology, Faculty of Sciences, Islamic Azad UniversityKaraj branch, Karaj, Iran
Abbas Ahmadi - Department of Chemistry, Faculty of Sciences, Islamic Azad University-Karaj ranch, Karaj, Iran
Ali-Akbar Salari - Young Researchers Club, Islamic Azad University-Karaj ranch, Kara, Iran

Abstract:

Objective(s) Anxiety is a common disorder which afflicts many people in any society and is often accompanied by physiological sensations such as tachycardia, chest pain, shortness of breath, insensitivity, etc. The purpose of present study was to evaluate the putative anxiolytic-like effects of phencyclidine ('-('-phenylcyclohexyl) piperidine, CAS ۹۵۶-۹۰-۱, PCP, I) and its methyl and methoxy hydroxyl derivatives (II, III) using elevated plus maze test of anxiety. Materials and Methods Phencyclidine as well as its methyl and methoxy hydroxyl derivatives (I, II, III) (hydrochloride, ۱, ۲, ۵ mg/kg) were synthesized and administrated intraperitoneally (IP) on adult male Wistar rats. Results The results of this study demonstrated that, intraperitoneal (IP) administration of PCP analogues (I, II, III) hydrochloride (۱, ۲, ۵ mg/kg) increases the percentage of open arm time (OAT%) and percentage of open arm entries (OAE%). Conclusion This study revealed that both derivatives of phencyclidine (II, III) were more effective than PCP (I) itself in modulation of anxiety behavior in rats.

Keywords:

Anxiety , Methyl and methoxy hydroxyl derivatives , Phencyclidine

Paper COI Code

This Paper COI Code is JR_IJBMS-13-2_003. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1296787/

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Hajkhani, Ramin and Solati, Jalal and Ahmadi, Abbas and Salari, Ali-Akbar,1389,The Effect of Phencyclidine New Derivatives on Anxiety Behaviors in Rats,https://civilica.com/doc/1296787

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Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: Azad University
Paper count: 9,551
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