Ramin Hajkhani - Department of Biology, Faculty of Sciences, Islamic Azad UniversityKaraj branch, Karaj, Iran
Jalal Solati - Department of Biology, Faculty of Sciences, Islamic Azad UniversityKaraj branch, Karaj, Iran
Abbas Ahmadi - Department of Chemistry, Faculty of Sciences, Islamic Azad University-Karaj ranch, Karaj, Iran
Ali-Akbar Salari - Young Researchers Club, Islamic Azad University-Karaj ranch, Kara, Iran

Objective(s) Anxiety is a common disorder which afflicts many people in any society and is often accompanied by physiological sensations such as tachycardia, chest pain, shortness of breath, insensitivity, etc. The purpose of present study was to evaluate the putative anxiolytic-like effects of phencyclidine ('-('-phenylcyclohexyl) piperidine, CAS ۹۵۶-۹۰-۱, PCP, I) and its methyl and methoxy hydroxyl derivatives (II, III) using elevated plus maze test of anxiety. Materials and Methods Phencyclidine as well as its methyl and methoxy hydroxyl derivatives (I, II, III) (hydrochloride, ۱, ۲, ۵ mg/kg) were synthesized and administrated intraperitoneally (IP) on adult male Wistar rats. Results The results of this study demonstrated that, intraperitoneal (IP) administration of PCP analogues (I, II, III) hydrochloride (۱, ۲, ۵ mg/kg) increases the percentage of open arm time (OAT%) and percentage of open arm entries (OAE%). Conclusion This study revealed that both derivatives of phencyclidine (II, III) were more effective than PCP (I) itself in modulation of anxiety behavior in rats.

Anxiety, Methyl and methoxy hydroxyl derivatives, Phencyclidine