Protective Effect of Aqueous and Ethanolic Extracts of Portulaca Oleracea Against Cisplatin Induced Nephrotoxicity

Publish Year: 1389
نوع سند: مقاله ژورنالی
زبان: English
View: 196

This Paper With 5 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-13-2_005

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s) Portulaca oleracea L. is a herbaceous weed from portulacaceae family. It can be found in many parts of the world. Modern pharmacological studies have demonstrated that P. oleracea have antioxidant effects. The protective effect of aqueous and ethanolic extract of P. oleracea against cisplatin-induced renal toxicity was studied in rats. Materials and Methods Single intraperitoneal injection of ۴ mg/kg cisplatin was administrated to rats. After ۵ days, blood urea nitrogen (BUN) and serum creatinine (Scr) concentration were determined. Effect of aqueous and ethanolic extracts, before and after cisplatin injection on BUN and Scr, as well as morphological renal damage, was evaluated. Results It was indicated that treatment with aqueous and ethanolic extracts of P. oleracea in the highest dose (۰.۸ and ۲ g/ kg), ۶ and ۱۲ hr before cisplatin injection reduced BUN and Scr. Tubular necrotic damage was not observed either. Conclusion Results suggest that P. oleracea extract may protect against cisplatin-induced renal toxicity and might serve as a novel combination agent with cisplan to limit renal injury.

Authors

Gholamreza Karimi

Medical Toxicology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Alireza Khoei

Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abbas Omidi

Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mahmudreza Kalantari

Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Javad Babaei

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Elahe Taghiabadi

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Bibi Marjan Razavi

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • ۱.Lim YY, Quah EPL. Antioxidant properties of different cultivars of ...
  • ۲.Brickell C. Encyclopedia of Gardening. London: Dorling Kindersley; ۱۹۹۲ ...
  • ۳.Chan K, Islam MW, Kamil M, Radhakrishnan R, Zakaria MNM, ...
  • ۴.Okwuasaba F, Ejika C, Parry O. Effects of extracts of ...
  • ۵.Radhakrishnan R,Zakaria MN, Islam MW, Chen HB, Kamil M, Chan ...
  • ۶.Abas F, Lajis NH, Israf DA, Khozirah S, Kalsom YU. ...
  • ۷.Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity ...
  • ۸.Simopoulos AP. Omega-۳ fatty acids and antioxidants in edible wild ...
  • ۹.Yen GC, Chen HY, Peng HH. Evaluation of the cytotoxicity, ...
  • ۱۰.Giaccone G. Clinical perspectives on platinum resistance. Drugs ۲۰۰۰; ۴:۹-۱۷ ...
  • ۱۱.Lee KW, Jeong JY, Lim BJ, Chang Y-K, Lee S-J, ...
  • ۱۲.Tsuruya K, Ninomiya T, Tokumoto M, Hirakawa M, Masutani K, ...
  • ۱۳.Kuhlmann MK, Horsch E, Burkhardt G, Wagner M, Kohler H. ...
  • ۱۴.Baliga R, Zhang Z, Baliga M, Ueda N, Shah SV. ...
  • ۱۵.McClatchey KD. Clinical Laboratory Medicine London Williams & Wilkins; ۱۹۹۴ ...
  • ۱۶.Hammersen F. Histology. Munich: Urban and Schwarzenberg;۱۹۸۵ ...
  • ۱۷.Karimi G, Ramezani M, Tahoonian Z. Cisplatin nephrotoxicity and protection ...
  • ۱۸.Heidman HT, Gerkens JF, Jackson EK, Branch RA. Attenuation of ...
  • ۱۹.Montine TJ, Borch RF. Role of endogenous sulfur containing nucleophiles ...
  • ۲۰.Rao M, Rao MMJ. Protective effects of selenomethionine against cisplatin-induced ...
  • ۲۱.Maliakel DM, Kagiya TV, Nair CKK. Prevention of cisplatin-induced nephrotoxicity ...
  • ۲۲.Gaedeke J, Fels LM, Bokemeyer C, Mengs U, Stolte H, ...
  • ۲۳.Chan K, Islam MW, Kamil M, Radhakrishnan R, Zakaria MN, ...
  • ۲۴.Deng J, Kohda Y, Chiao H, Wang Y, Hu X, ...
  • ۲۵.Ramesh G, Reeves WB. TNF-alpha mediates chemokine and cytokine expression ...
  • نمایش کامل مراجع