Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type ۴ protein expression in the skeletal muscles of rats during endurance exercise
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 19، Issue: 1
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-19-1_003
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type ۴ (GLUT-۴) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) sedentary group, n = ۸), CS (۱.۰% CLA supplemented HFD sedentary group, n = ۸), and CE (۱.۰% CLA supplemented HFD exercise group, n = ۸). The rats in the CE swam for ۶۰ min a day, ۵ days a week for ۸ weeks. Results:The serum glucose and insulin contents and homeostasis model assessment of insulin resistance (HOMA-IR) value of the CS and CE were significantly decreased compared to those of the HS. The PPAR-γ protein expressions in the soleus muscle (SOM) and extensor digitorum longus muscle (EDL) were significantly higher in the CE than in the HS. In addition, the PPAR-γ protein expression in the SOM of the CS was significantly higher than that in the HS. On the other hand, the GLUT-۴ protein expression of the SOM in the CE was significantly higher compared to that in the HS. However, there was no significant difference in GLUT-۴ protein expression in the EDL among the groups. Conclusion:CLA supplementation with/without endurance exercise has role in improvement of insulin sensitivity. Moreover, when CLA supplementation was accompanied by endurance exercise, the PPAR-γ protein expression in SOM and EDL and the GLUT-۴ protein expression in SOM were enhanced compared with the control group.
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Authors
Kangok Cho
Institute of Sports Health Science, Sunmoon University, Asan city, Chung Nam, ۳۸۰-۷۰۱, S. Korea
Youngju Song
Institute of Sports Health Science, Sunmoon University, Asan city, Chung Nam, ۳۸۰-۷۰۱, S. Korea
Daekeun Kwon
Institute of Sports Health Science, Sunmoon University, Asan city, Chung Nam, ۳۸۰-۷۰۱, S. Korea
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