Evaluation of the circulating levels of IL-۱۲ and IL-۳۳ in patients with breast cancer: influences of the tumor stages and cytokine gene polymorphisms

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-18-12_005

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s):IL-۱۲ as an anti-tumor cytokine and IL-۳۳ a novel identified cytokine with both pro- or anti-tumor activities, play important roles in response against tumor cells. Our aim was to evaluate the IL-۱۲ and IL-۳۳ levels and single nucleotide polymorphisms (SNP) in their genes in patients with breast cancer. Materials and Methods:Blood samples were collected from ۱۰۰ patients with breast cancer, and ۱۰۰ healthy women were controls. The serum IL-۱۲ and IL-۳۳ levels were measured by ELISA. The SNP rs۳۲۱۲۲۲۷ (in IL-۱۲ gene) and rs۱۹۲۹۹۹۲ (in IL-۳۳ gene) were determined using PCR-RFLP. Results:The IL-۱۲ levels similarly expressed in patients and controls. IL-۱۲ levels in patients at stage I were significantly lower than in the healthy group (P<۰.۰۵). IL-۳۳ levels and the IL-۳۳/IL-۱۲ ratio were significantly higher in patients than the control group (P<۰.۰۰۱). The IL-۳۳ levels and IL-۳۳/IL-۱۲ ratio in stage IV patients were significantly higher than other stages and controls (PP<۰.۰۰۱, respectively). There were no significant differences in the frequencies of genotypes in rs۳۲۱۲۲۲۷ and rs۱۹۲۹۹۹۲ between patients and the control group. No significant differences were observed between subjects with various genotypes at rs۳۲۱۲۲۲۷ and rs۱۹۲۹۹۹۲ with respect to related cytokine levels. Conclusion:These results indicate that the diminished IL-۱۲ production may contribute to the tumor establishment. The higher IL-۳۳ levels and IL-۳۳/IL-۱۲ ratio in patients also indicate an imbalance in Th۱/Th۲ responses that may contribute to tumor development. Thus, correcting the imbalance of Th۱/Th۲ could be an important strategy for cancer immunotherapy.

Authors

Abdollah Jafarzadeh

Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Kayhan Minaee

Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran

Ali-Reza Farsinejad

Department of Laboratory Sciences, Paramedical School, Kerman University of Medical Sciences, Kerman, Iran

Maryam Nemati

Department of Laboratory Sciences, Paramedical School, Kerman University of Medical Sciences, Kerman, Iran

Arezu Khosravimashizi

Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran

Hamid Daneshvar

Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran

Mohammad Mehdi Mohammadi

Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran

Abdolkarim Sheikhi

Department of Immunology, Medical School, Dezful University of Medical Sciences, Dezful, Iran

Abbas Ghaderi

Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

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  • Coughlin SS, Ekwueme DU. Breast cancer as a global health ...
  • Hamidullah, Changkija B, Konwar R. Role of interleukin-۱۰ in breast ...
  • Soliman H. Immunotherapy strategies in the treatment of breast cancer. ...
  • Kees T, Egeblad M. Innate immune cells in breast cancerfrom ...
  • Gruber I, Landenberger N, Staebler A, Hahn M, Wallwiener D, ...
  • Standish LJ, Sweet SE, Novack J,Wenner CA, Bridge C, Nelson ...
  • DeNardo DG, Coussens LM. Inflammation and breastcancer. Balancing immune response: ...
  • Carpi A, Nicolini A, Antonelli A, Ferrari P, Rossi G. ...
  • Konwar R, Chaudhary P, Kumar S, Mishra D, Chattopadhyay N,Bid ...
  • Chen YY, Li CF, Yeh CH, Chang MS, Hsing CH. ...
  • Laoui D, Movahedi K, Van Overmeire E, Van den Bossche ...
  • Zhu J, Paul WE. Heterogeneity and plasticity of T helper ...
  • Faghih Z, Erfani N, Haghshenas MR, Safaei A, Talei AR, ...
  • Kennedy R, Celis E. Multiple roles for CD۴+ T cells ...
  • Zhang Y, Zhang Y, Gu W, Sun B. TH۱/TH۲ cell ...
  • Nishikawa H, Sakaguchi S. Regulatory T cells in cancer immunotherapy. ...
  • Jafarzadeh A, Fooladseresht H, Minaee K, Bazrafshani MR, Khosravimashizi A, ...
  • Lasek W, Zagozdzon R, Jakobisiak M. Interleukin ۱۲: still a ...
  • de Paus RA, Geilenkirchen MA, van Riet S, van Dissel ...
  • Croxford AL, Kulig P, Becher B. IL-۱۲-and IL-۲۳ in health ...
  • Chen H, Cheng S, Wang J, Cao C, Bunjhoo H, ...
  • Sattler S, Smits HH, Xu D, Huang FP. The evolutionary ...
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  • Nakae S, Morita H, Ohno T, Arae K, Matsumoto K, ...
  • Bourgeois E, Van LP, Samson M, Diem S, Barra A, ...
  • Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S. ...
  • Zhou L, Yao F, Luan H, Wang Y, Dong X, ...
  • Yang Z, Liang Y, Qin B, Zhong R. Meta-analysis of ...
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  • Fan D, Ding N, Yang T, Wu S, Liu S, ...
  • Guo L, Zhou X, Guo X, Zhang X, Sun Y. ...
  • Koca SS, Kara M, Deniz F, Ozgen M, Demir CF, ...
  • Mahdi KM, Nassiri MR, Nasiri K. Hereditary genes and SNPs ...
  • Murakami S, Okubo K, Tsuji Y, Sakata H, Hamada S, ...
  • Miteva L, Stanilov N, Deliysky T, Mintchev N, Stanilova S. ...
  • Yuzhalin AE, Kutikhin AG. Interleukin-۱۲: clinical usage and molecular markers ...
  • Liu J, Shen JX, Hu JL, Huang WH, Zhang GJ. ...
  • Bourgeois E, Van LP, Samson M, Diem S, Barra A, ...
  • Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, ...
  • Jovanovic I, Radosavljevic G, Mitrovic M, Lisnic Juranic V, McKenzie ...
  • Liew FY, Pitman PN, McInnes IB. Disease-associated function of IL-۳۳: ...
  • Jovanovic I, Radosavljevic G, Mitrovic M, Juranic VL, McKenzie AN, ...
  • Jovanovic IP, Pejnovic NN, Radosavljevic GD, Arsenijevic NN, Lukic ML. ...
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